Administration of these doses was also associated with severe maternal toxicity. These doses are approximately 0. All doses caused hyperactivity and decreased weight gain in the dams. A decrease in pup survival was seen at all doses.
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A number of studies in rodents indicate that prenatal or early postnatal exposure to amphetamine d- or d, l- , at doses similar to those used clinically, can result in long-term neurochemical and behavioral alterations. Reported behavioral effects include learning and memory deficits, altered locomotor activity, and changes in sexual function. There are no adequate and well-controlled studies in pregnant women. There are limited published data on the use of amphetamine in pregnant women.
These data are insufficient to determine a drug-associated risk of major congenital malformations or miscarriage. Amphetamines should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. In addition, amphetamines can stimulate uterine contractions increasing the risk of premature delivery.
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Premature delivery and low birth weight infants have been reported in amphetamine-dependent mothers. Monitor infants born to mothers taking amphetamines for symptoms of withdrawal, such as feeding difficulties, irritability, agitation, and excessive drowsiness. Acidifying agents can decrease amphetamine blood levels, while alkalinizing agents can increase amphetamine blood levels.
MAO Inhibitors MAOI Clinical Impact MAOI antidepressants slow amphetamine metabolism, increasing amphetamines effect on the release of norepinephrine and other monoamines from adrenergic nerve endings causing headaches and other signs of hypertensive crisis. Toxic neurological effects and malignant hyperpyrexia can occur, sometimes with fatal results. Examples selective serotonin reuptake inhibitors SSRI , serotonin norepinephrine reuptake inhibitors SNRI , triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, St.
Examples Gastrointestinal alkalinizing agents e. Urinary alkalinizing agents e. Acidifying Agents Clinical Impact Lower blood levels and efficacy of amphetamines. Intervention Increase dose based on clinical response.
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Examples Gastrointestinal acidifying agents e. Tricyclic Antidepressants Clinical Impact May enhance the activity of tricyclic or sympathomimetic agents causing striking and sustained increases in the concentration of d-amphetamine in the brain; cardiovascular effects can be potentiated. Intervention Monitor frequently and adjust or use alternative therapy based on clinical response. Examples desipramine, protriptyline 7.
This increase is greatest in the evening. Amphetamines may interfere with urinary steroid determinations. Below is a description of the results of the adequate and well-controlled studies of mixed salts of a single-entity amphetamine product extended-release capsules MAS ER in the treatment of ADHD. Patients were randomized to fixed-dose treatment groups receiving final doses of 10, 20 or 30 mg of mixed salts of a single-entity amphetamine product extended-release capsules or placebo once daily in the morning for three weeks. Patients were randomized to receive final doses of 10 mg, 20 mg, 30 mg, and 40 mg MAS ER or placebo once daily in the morning.
Patients randomized to doses greater than 10 mg were titrated to their final doses by 10 mg each week. Improvements in the primary cohort were statistically significantly greater in all four primary cohort active treatment groups MAS ER 10 mg, 20 mg, 30 mg, and 40 mg compared with the placebo group.
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Patients were randomized to fixed-dose treatment groups receiving final doses of 20, 40, or 60 mg of MAS ER or placebo once daily in the morning for four weeks. In adults, sudden death, stroke, and myocardial infarction have been reported. Avoid use in patients with known structural cardiac abnormalities, cardiomyopathy, serious heart arrhythmia, or coronary artery disease. Dextroamphetamine Sulfate is a central nervous system stimulant medication.
It is widely used in treating attention deficit hyperactivity disorder ADHD mostly in children. Dextroamphetamine Sulfate can also be used to treat narcolepsy which is a type of sleeping disorder.
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Dextroamphetamine Sulfate works by affecting or restoring the balance certain chemicals in the brain that are known for causing these conditions. It improves the ability to stay focused, pay attention and stop fidgeting in patients.
The drug is mostly supplied in the form of capsules most of the time. Dextroamphetamine Sulfate dosage should be determined by the condition that the patient is in. Get Dextroamphetamine Coupon. Dextroamphetamine Info Coupon. All you have to do is print the coupon and bring it to the pharmacy to receive the benefits of our drug discount program. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition.
This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis.
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Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen. Every effort has been made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. The information on this page has been compiled for use by healthcare practitioners and consumers in the United States and therefore neither Everyday Health or its licensor warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.
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